Dr. Jennifer Melfi

"Two years ago I thought RICO was a relative of his."

Dr. Jennifer Melfi is probably the last person anyone would expect to be associated with organized crime. Her private life is unassuming; she's divorced with a son who attends Bard College. Professionally, she is a respected psychiatrist in private practice. One day, however, she opened the door to her waiting room and came face to face with la cosa nostra personified: Tony Soprano. Referred by his neighbor, the notorious capo was seeking treatment for anxiety attacks. That meeting was a seminal event in Melfi's life — one that she often wishes had never happened.

Though she's frustrated with his inability to tell her things, in the end, Dr. Melfi may be the only person who truly knows Tony Soprano.